Are we on the brink of a psychedelic revolution? It’s seeming more and more likely. A scientific review of the existing research into the therapeutic applications of psychedelics, published in the Canadian Medical Association Journal, highlights the enormous potential of substances like LSD, psilocybin (hallucinogenic mushrooms) and MDMA (the active ingredient in Ecstasy) for treating a host of mental health issues, including post-traumatic stress disorder, addiction, anxiety associated with terminal illness and depression. “The studies are showing big effects,” Matthew Johnson, a behavioral pharmacologist at Johns Hopkins University and one of the study’s authors, told The Huffington Post. “The exciting thing isn’t just that these drugs work for something that we already have treatment for. It’s that they’re getting big effects on disorders for which we have very poor treatment.”