Today’s Solutions: July 21, 2024

Alopecia can be extremely disheartening and drastically alter someone’s confidence and self-image. The condition affects men and women, and scientists are looking into different treatments and possible cures for the different forms of alopecia. 

Researchers have identified a molecule that determines whether or not hair regrows. This molecule is called SCUBE3, and it could lead to new treatments for alopecia

Discovery and regrowth 

It is well known that dermal papilla cells at the bottom of each hair follicle are responsible for the continued regrowth of hair. However, the genetic reason for how these cells are activated was a mystery. That was until researchers from the University of California, Irvine discovered the SCUBE3 molecule. 

“At different times during the hair follicle life cycle, the very same dermal papilla cells can send signals that either keep follicles dormant or trigger new hair growth,” says corresponding author Maksim Plikus, a professor of developmental and cell biology.

“We revealed that the SCUBE3 signaling molecule, which dermal papilla cells produce naturally, is the messenger used to ‘tell’ the neighboring hair stem cells to start dividing, which heralds the onset of new hair growth.”

For people with androgenic alopecia, activating the dermal papilla cells is the key to solving their hair loss. These cells in alopecia patients are malfunctioning, but researchers believe that SCUBE3 is the key to reversing this process. Tests on mice proved them correct. Lab mice who had transplanted human scalp follicles were micro-injected with SCUBE3 and this induced new hair growth in the human and mice follicles on the mice.

This discovery bodes well for the future of alopecia treatment and possible new medications. 

“There is a strong need for new, effective hair loss medicines, and naturally occurring compounds that are normally used by the dermal papilla cells present ideal next-generation candidates for treatment,” Plikus says. “Our test in the human hair transplant model validates the preclinical potential of SCUBE3.”

Source Study: Developmental CellHedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state – ScienceDirect

Solutions News Source Print this article
More of Today's Solutions

3 lifestyle hacks to help you become a little happier

There is no one path to finding happiness, but there are some lifestyle changes you can make to become more receptive to happiness. Without ...

Read More

This simple trick can significantly boost your brain health

We recently shared a few habits you can integrate within your day-to-day life to improve your brain health. Now, we’d like to bring you ...

Read More

CO2 emissions significantly reduced at the last Olympic Games

The Pandemic turned everyone’s world upside down, causing us all to adapt to new ways of life and society to find a new “normal.” ...

Read More

The Supreme Court of Brazil upholds indigenous land rights: a victory for con...

Brazil's Supreme Court maintained Indigenous communities' land rights in a landmark decision, putting an end to the prospect of potential rollbacks on these critical ...

Read More